宋浩，博士，二级教授，博士生导师，院长。37000cm威尼斯合成生物学研究所所长。曾获国家万人计划科技创新领军人才，科技部中青年科技创新领军人才，国家高层次青年人才称号。中国生物工程学会合成生物学专业委员会副主任。科技部合成生物学重点研发专项首席科学家。教授合成生物学、基因线路设计构建与应用等本科和研究生课程。
教育和工作经历
1990.09-1994.06 南开大学化学专业，理学学士
1994.09-1999.06 南开大学物理化学专业，理学博士
1999.09-2004.08 休斯顿大学（美国），化学工程学院，化工专业，工学博士
2004.10-2006.09 得克萨斯大学（美国），休斯顿医学中心，神经生物学系，博士后
2006.10-2009.09 杜克大学（美国），生物医学工程系，Research Associate
2009.10-2013.05南洋理工大学（新加坡），化工与生物医学工程系，助理教授
2013.06-2024.12天津大学，化工学院，教授，制药工程系系主任（期间2021.01- 2024.12，天津大学讲席教授（二级教授））
2025.01-至今 37000cm威尼斯（二级教授），37000cm威尼斯，院长
主要科研方向
1.合成生物学：基因线路，基因组编辑，细胞治疗
2.人工智能AI驱动的绿色生物制造：
（1）光电遗传学：应用于碳中和（电能细胞，微生物电合成固定CO2合成高值化学品，单细胞蛋白合成，生物固氮），生物冶金（稀土、贵金属）
（2）人工细胞工厂设计构建：代谢工程，蛋白质/酶工程，应用于高价值化学品、功能高分子材料的绿色生物制造
（3）生物制药：生物合成多肽（GLP-1等）、蛋白（胶原蛋白等）、核苷类药物；维生素（K2, B12, A等）、甜味剂、色素、角鲨烯等营养健康产品
主持的基金项目
1.科技部合成生物学重点研发专项：项目名称：电能细胞设计与构建；项目编号：2018YFA0901300；项目资助金额：1996万元, 主持（首席科学家）。
2.国家自然科学基金面上项目：项目名称：固定二氧化碳合成葡萄糖的微生物-无机杂化人工光合系统设计构建；项目编号：NSFC 22378305；项目资助金额：50万元，主持。
3.国家自然科学基金面上项目：项目名称：还原力动态调控分配驱动的智能微生物电合成系统设计构建；项目编号：NSFC 32071411；项目资助金额：58万元，主持。
4.国家自然科学基金面上项目：项目名称：希瓦氏菌电子传递途径改造实现微生物高效电合成研究；项目编号：NSFC 21376174；项目资助金额：80万元，主持。
5.国家海洋局：项目名称：高效微生物采油技术和装备开发及产业化示范；项目编号：BHSF2017-06；项目资助金额：728万元，主持。
6.中化（央企），及多家大中型医药企业：横向合作委托研发项目。
代表性论文
1.Huan Yu, Feng Li, Yuxuan Wang, Chaoning Hu, Chunxiao Qiao, Fei Lan, Baocai Zhang, Liang Shi, Haichun Gao, Kenneth H. Nealson, and Hao Song*. Electro-controlled distribution of reducing equivalents to boost isobutanol biosynthesis in microbial electro-fermentation of S. oneidensis, Joule, 2025, 9, 101773.
2.Wang Ye, Yao Tian, Dake Xu, Shaoan Cheng, Wen-Wei Li, and Hao Song*. Recent advances in synthetic biology toolkits and metabolic engineering of Ralstonia eutropha H16 for production of value-added chemicals, Biotechnology Advances, 2025, 79, 108516.
3.Junqi Zhang, Wenjing Lv, Yangyang Wang, Jingxuan Tan, Chao Li, Dingyuan Liu, Longhai Dai, Jing Zou, Zhanying Liu, Wen Wei Li, Guosheng Xin, Feng Li, and Hao Song*. Engineering Shewanella oneidensis to efficiently co-utilize glucose and xylose for converting cellulose hydrolysate from corn stover to electricity”, Chemical Engineering Journal, 2025, 505, 159574.
4.Wenqi Ding, Tong Lin, Yun Yang, Dake Xu, Wen-Wei Li, Shaoan Cheng, and Hao Song*. The proton motive force generated by microbial rhodopsin promotes extracellular electron transfer, Synthetic and Systems Biotechnology, 2025, 10, 410-420.
5.Junqi Zhang, Feng Li, Dingyuan Liu, Qijing Liu, Hao Song*. Synthetic biology engineering bi-directional extracellular electron transfer of electroactive microorganisms for energy and chemicals production, Chemical Society Reviews, 2024, 53, 1375-1446.
6.Wenqi Ding, Tong Lin, Danni Zhang, Yun Yang, Feng Li, Dake Xu*, Derek R. Lovley*, and Hao Song*. Expression of the Geobacter Extracellular Cytochrome OmcS in Shewanella oneidensis, Biotechnology and Bioengineering, 2024, 121(6): 2002-2012.
7.Qijing Liu, Wenliang Xu, Qinran Ding, Yan Zhang, Longhai Dai, Cheng Zhong, Wenyu Lu, ZhanYing Liu, Feng Li, Hao Song*. Engineering Shewanella oneidensis-bacterial cellulose-based aerogel coated anthraquinone biohybrid electrode to boost energy and chemicals production, Advanced Science, 2024, 11, 2407599.
8.Feng Li, Huan Yu, Baocai Zhang, Fei Lan, Yuxuan Wang, Rui Tang, Zixuan You, Qijing Liu, Junqi Zhang, Chao Li, Liang Shi, Wen-Wei Li, Kenneth Nealson, ZhanYing Liu, Hao Song*. Engineered cell elongation promotes extracellular electron transfer of Shewanella oneidensis, Advanced Science, 2024, 11, 2403067.
9.Huan Yu, Fei Lan, Chaoning Hu, Longhai Dai, Baocai Zhang, Zixuan You, Liang Shi, Zhanying Liu, Feng Li, and Hao Song*. Accelerating cell division of Shewanella oneidensis to promote extracellular electron transfer rate for efficient pollution treatment, Chemical Engineering Journal, 1 August 2024, Volume 493, 152765.
10.Deguang Wu, Baocai Zhang, Sicheng Shi, Rui Tang, Jichao Jia, Xiaoguang Si, Yifei, Wang, Xi Sun, Dongguang Xiao, Feng Li, Hao Song*. Engineering extracellular electron transfer to promote simultaneous brewing wastewater treatment and chromium reduction, Journal of Hazardous Materials, 2024, 5:465:133171.
11.Zixuan You, Jianxun Li, Yuxuan Wang, Feng Li, Hao Song*. Advances in mechanisms and engineering of electroactive biofilms, Biotechnology Advances, 2023, 66: 108170.
12.Baocai Zhang, Sicheng Shi, Rui Tang, Huan Yu, Shulin Shao, Feng Li, Hao Song*. Recent advances in enrichment, isolation, and bio-electrochemical activity evaluation of exoelectrogenic microorganisms, Biotechnology Advances, 2023, 66: 108175.
13.Junqi Zhang, Zixuan You, Li Feng, Hao Song*. Conductive proteins-based extracellular electron transfer of electroactive microorganisms, Quantitative Biology, 2023,11:405–420.
14.Qijing Liu, Qinran Ding, Wenliang Xu, Yan Zhang, Baocai Zhang, Huan Yu, Zixuan You, Chao Li, Junqi Zhang, Rui Tang, Deguang Wu, Chao Zhao, Yingxiu Cao, Feng Li, Hao Song*. Engineering cell-electrode interfacial electron transfer to boost power generation of electroactive biofilm, Nano Energy, 2023, 117: 108931.
15.Jin, Shixuan; Feng, Yiyu; Jia, Jichao; Zhao, Fulai; Wu, Zijie; Long, Peng; Li, Feng; Yu, Huitao; Yang, Chi; Liu, Qijing; Zhang, Baocai;Song, Hao*; Feng, Wei*. Three-dimensional N-doped carbon nanotube/graphene composite aerogel anode to develop high-power microbial fuel cell, Energy & Environmental Materials, 2023, 6, e12373.
16.Feng Li, Rui Tang, Baocai Zhang, Chunxiao Qiao, Huan Yu, Qijing Liu, Junqi Zhang, Deguang Wu, Liang Shi, and Hao Song*, Systematic full-cycle engineering microbial biofilms to boost electricity production in Shewanella oneidensis, Research, 15 March 2023, Vol. 6, 0081.
17.Kai Li, Jia-Wei Zhang, Feng Li, Xin-Qing Zhao, Feng-Wu Bai, Hao Song*, Chen-Guang Liu*. Electrochemical Control of Cell Metabolism Improves Ethanol Production of Zymomonas mobilis in an Electro-Fermentation System, ACS Sustainable Chemistry & Engineering, 2023, 11 (6): 2364-2374.
18.Congcong Huang, Yaru Chen, Shuai Cheng, Mengxu Li, Luxin Wang, Meijie Cheng, Feng Li, Yingxiu Cao, Hao Song*. Enhanced acetate utilization for value-added chemicals production in Yarrowia lipolytica by integration of metabolic engineering and microbial electrosynthesis, Biotechnology and Bioengineering, 2023, 120 (10): 3013-3024.
19.Yaru Chen, Meijie Cheng, Lin Wang,Lixia Fang, Yingxiu Cao, Hao Song*. Highly efficient multiplex base editing: one-shot deactivation of eight genes in Shewanella oneidensis MR-1, Synthetic and Systems Biotechnology, 2023, 8 (1), 1-10.
20.Qinran Ding, Qijing Liu, Yan Zhang, Feng Li, Hao Song*. Modular engineering strategy to redirect electron flux into electron transfer chain for enhancing extracellular electron transfer in Shewanella oneidensis, ACS Synthetic Biology, 2023 Feb 17;12(2):471-481.
21.Huan Yu, Yujun Lu, Fei Lan, Yuxuan Wang, Chaoning Hu, Lingfeng Mao, Deguang Wu, Feng Li, Hao Song*. Engineering outer membrane vesicles to increase extracellular electron transfer of Shewanella oneidensis, ACS Synthetic Biology, 2023, 6, 1645-1656.
22.Nan Yang, Yao Tian, Mai Zhang, Feng Li, Xiting Peng, Jianxun Li, Yi Li, Bei Fan, Fengzhong Wang, and Hao Song*. Photocatalyst-Enzyme Hybrid Systems for Light-Driven Biotransformation, Biotechnology Advances, 2022, 54: 107808.
23.Changjiang Liu, Huan Yu, Baocai Zhang, Chenguang Liu, Feng Li, Hao Song*. Engineering whole-cell microbial biosensors: design principles and applications in monitoring and treatment of heavy metals and organic pollutants, Biotechnology Advances, 2022, 60: 108019.
24.Enze Zhou, Feng Li, Dawei Zhang, Dake Xu*, Zhong Li, Ru Jia, Yuting Jin, Hao Song*, Huabing Li, Qiang Wang, Jianjun Wang, Xiaogang Li, Tingyue Gu, Axel M. Homborg, Johannes M.C. Mol, Jessica A. Smith, Fuhui Wang. Direct microbial electron uptake as a mechanism for stainless steel corrosion in aerobic environments, Water Research, 2022, 219, 118553.
25.Lixia Fang, Jie Fan, Congya Wang,Yingxiu Cao, Hao Song*. Genome-scale target identification in Escherichia coli for high-titer production of free fatty acids, Nature Communications, 2021, 12:4976.
26.Shaomei Yang,Yingxiu Cao,Liming Sun,Congfa Li,Xue Lin,Zhigang Cai,Guoyin Zhang,Hao Song*. Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis of menaquinone-7, ACS Synthetic Biology, 2019, 8 (1), 70–81.
27.Feng Li, Yuanxiu Li, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song*. Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis, Nature Communications (2018) 9:3637.
28.Tong Lin, Wenqi Ding, Liming Sun, Lei Wang, Chen-Guang Liu, Hao Song*. Engineered Shewanella oneidensis-reduced graphene oxide biohybrid with enhanced biosynthesis and transport of flavins enabled a highest bioelectricity output in microbial fuel cells, Nano Energy, 50 (2018) 639–648.
29.Chen Xiaoli#, Cao Yingxiu#, Li Feng#, Tian Yao, Hao Song*. Enzyme-Assisted Microbial Electrosynthesis of Poly(3-hydroxybutyrate) via CO2 Bioreduction by Engineered Ralstonia eutropha, ACS Catalysis, 2018, 8, 4429−4437.
30.Li, Feng, Li, Yuanxiu, Sun, Liming, Chen, Xiaoli, An, Xingjuan, Yin, Changji, Cao, Yingxiu, Wu, Hui, Song, Hao*. “Modular engineering intracellular NADH regeneration boosts extracellular electron transfer of Shewanella oneidensis MR-1”, ACS Synthetic Biology, 2018, 7(3): 885–895.
31.Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Liwi, Hong Liu, Baode Sun, Heming Xu, Jiamei zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Hao Song*, Yingjin Yuan*. A three-species microbial consortium for power generation, Energy & Environmental Science, 2017, 10, 1600-1609.
32.Yun Yang, Yichao Wu, Yidan Hu, Yingxiu Cao, Poh Chueh Loo, Cao Bin*, Hao Song*. Engineering Electrode-Attached Microbial Consortia for High-Performance Xylose-Fed Microbial Fuel Cell, ACS Catalysis, 2015, 5 (11), 6937–6945.
33.Yun Yang, Yuanzhao Ding, Yidan Hu, Bin Cao, Scott A. Rice, Staffan Kjelleberg, Hao Song*. Enhancing bidirectional electron transfer of Shewanella oneidensis by a synthetic flavin pathway, ACS Synthetic Biology, 4 (7), 815–823 (2015).
34.Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song*. Highly Active Bidirectional Electron Transfer by a Self-Assembled Electroactive Reduced-Graphene-Oxide-Hybridized Biofilm, Angewandte Chemie International Edition, 53, 4480-4483 (2014).
35.Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan*. "Synthetic microbial consortia: from systematic analysis to construction and applications", Chemical Society Reviews, 43, 6954-6981 (2014).
36.Hao Song, S. Payne, M. Gray, Lingchong You*. Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem, Nature Chemical Biology, 5, 929–935 (2009).
地址：辽宁省沈阳市浑南区创新路195号
邮编：110169
电话：18722024233
E-mail：songhao@mail.neu.edu.cn