黄永业，博士，副教授，硕士生导师。主要讲授《分子生物学》等课程，获批辽宁省一流本科课程，获辽宁省教学成果奖。获得省级科学技术进步一等奖1项；指导学生参加国际遗传工程机器竞赛（iGEM），获得金奖、银奖和单项提名奖；指导学生参加全国大学生生命科学竞赛，多次获得全国总决赛一等奖；连续获评校优秀毕业论文指导教师和学生创新创业活动优秀指导教师；指导研究生获国家奖学金。以副主编身份编写《分子生物学》教材1部，参编Humana Press出版书籍《Nuclear Reprogramming》。分别担任Journal of Cellular and Molecular Medicine杂志和Frontiers in Cell and Developmental Biology杂志副主编，担任Biology杂志和Oncology Letters杂志副主编。
教育和工作经历
2005.09-2009.06 吉林大学生物技术专业，理学学士
2009.09-2014.06 吉林大学生物化学与分子生物学专业，理学博士
主要科研方向
1. 探讨肿瘤防控的分子细胞机制，提升天然药物和RNA药物在抗肿瘤治疗中的应用。
2. 解析细胞重编程进程，研究促进胚胎发育和阻止细胞异常分化的策略。
主持的基金项目
1. 国家自然科学基金青年基金项目：BAP31调节膀胱癌干细胞干性及其相关机制研究，主持
2. 中央高校基本科研业务费项目：lncRNA H19调控白藜芦醇与紫檀芪抗肿瘤作用的机制研究，主持
3. 中央高校基本科研业务费项目：利用Crispr/Cas9技术研究BAP31敲除对膀胱癌细胞致瘤能力的影响，主持
4. 辽宁省自然科学基金项目医工交叉联合基金：壳聚糖修饰磁性纳米材料负载si-BATF/PRDM1的纳米颗粒递送抑制Treg细胞活化在前列腺癌免疫治疗中的机制研究，共同主持
5. 辽宁省教育厅高等学校基本科研项目（青年项目）：动员钙镁离子调节内质网稳态抑制肿瘤细胞存活研究，主持
6. 辽宁省自然基金资助计划面上项目：基于p53/ CDKN1A轴增效紫檀芪抑制肺癌干细胞的机制研究，主持
代表性论文
1. Lin Yuan, Feng Yue, Jacek Z Kubiak, Sen Wu, Yongye Huang. Applying large animals for developmental study and disease modeling. Frontiers in Cell and Developmental Biology. 2023.
2. Linglin Cheng, Shubo Li, Kailun He, Ye Kang, Tianye Li, Chunting Li, Yi Zhang, Wanlu Zhang, Yongye Huang. Melatonin regulates cancer migration and stemness and enhances the anti-tumour effect of cisplatin. Journal of Cellular and Molecular Medicine. 2023.
3. Yongye Huang, Yue Hou, Peng Qu, Yun Dai. Combating cancer with natural products: Non-coding RNA and RNA modification. Frontiers in Pharmacology. 2023.
4. Hongxiao Song, Yongye Huang, Chunfeng Li, Quan Liu, Guangyun Tan. Interferon and its antiviral effect in response to HBV infection. Frontiers in Immunology. 2023.
5. Wanlu Zhang, Shubo Li, Chunting Li, Tianye Li, Yongye Huang. Remodeling tumor microenvironment with natural products to overcome drug resistance. Frontiers in Immunology. 2022.
6. Yongye Huang, Jianguang Ji, Qi Zhao, Jun Song. Regulation of endoplasmic reticulum and mitochondria in cellular homeostasis. Frontiers in Cell and Developmental Biology. 2022.
7. Yating Sun, Dan Li, Hongmei Liu, Yongye Huang, Fanyu Meng, Jiahao Tang, Zhanjun Li, and Wanhua Xie. PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition. Cell Death and Disease. 2022; 13(5): 487.
8. Tianye Li , Zhenzhen Hao, Zihan Tang, Chunting Li , Linglin Cheng, Tao Wang, Xiaojin Zhu, Yunhao He, Yongye Huang and Bing Wang. BAP31 Regulates Wnt Signaling to Modulate Cell Migration in Lung Cancer. Front Oncol. 2022; 12: 1-14.
9. Tianye Li, Xinyue Zhang, Linglin Cheng, Chunting Li, Zihan Wu, Yingqi Luo, Kunpeng Zhou, Yanlin Li, Qi Zhao, Yongye Huang. Modulation of lncRNA H19 enhances resveratrol-inhibited cancer cell proliferation and migration by regulating endoplasmic reticulum stress. Journal of Cellular and Molecular Medicine. 2022.
10.Tianye Li, Zihan Tang, Chunting Li, Xiaoya Liu, Linglin Cheng, Zhijing Yang, Xiaojin Zhu, Weiwei Liu, Yongye Huang. Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway. Fronties in Pharmacology. 2022; 12: 1-14.
11.Yongye Huang, Hou Yue, Qu Peng, Cai Yong. Combating Cancer With Natural Products: What Would Non-Coding RNAs Bring?. Front Oncol. 2021; 11: 1-3.
12.Shuang Wu, Tianye Li, Weiwei Liu, Yongye Huang. Ferroptosis and Cancer: Complex Relationship and Potential Application of Exosomes. Frontiers in Cell and Developmental Biology. 2021; 9: 1-16.
13.Yongye Huang, Ziyan Zhou, Jin Zhang, Zhenzhen Hao, Yunhao He, Zihan Wu, Yiquan Song, Kexun Yuan, Shanyu Zheng, Qi Zhao, Tianye Li, Bing Wang. lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell. Journal of Cellular and Molecular Medicine. 2021, 25(15):7135-7145.
14.Yongye Huang, Kexun Yuan, Meifang Tang, Jiaming Yue, Lijun Bao, Shuang Wu, Yanxin Zhang, Yin Li, Yihang Wang, Xu Ou, Jiaxin Gou, Qi Zhao, Lin Yuan. Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras-Raf-MAPK signaling. Journal of Cellular and Molecular Medicine. 2021; 25(3): 1480-1492.
15.Tianye Li, Yu Yang, Shi Hang, Cao Yuhua, Liu Xiangfu Liu, Hao Zhenzhen Hao, Ren Yuping Ren, Gaowu Qin, Yongye Huang, Bing Wang. Magnesium in Combinatorial With Valproic Acid Suppressed the Proliferation and Migration of Human Bladder Cancer Cells. Front Oncol. 2020; 10: 1-17.
16.Xiang Yuening, Guo Zimu, Zhu Pengfei, Chen Jia, Yongye Huang. Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science. Cancer Med. 2019; 8: 1958-75.（ESI highly cited papers）
17.Yongye Huang, Du Juan, Mi Yan, Li Tianye, Gong Ying, Ouyang Hongsheng, Hou Yue. Long Non-coding RNAs Contribute to the Inhibition of Proliferation and EMT by Pterostilbene in Human Breast Cancer. Front Oncol. 2018; 8: 1-13.
18.Liu Siwei, Liang Bilin, Jia Huiting, Jiao Yuhan, Pang Zhongqiu, Yongye Huang. Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells. FEBS Open Bio. 2017; 7: 798-810.
19.Yongye Huang, Li Zhanjun, Wang Anfeng, Han Xiaolei, Song Yuning, Yuan Lin, Li Tianye, Wang Bing, Lai Liangxue, Ouyang Hongsheng, Pang Daxin. Chimerism in piglets developed from aggregated cloned embryos. FEBS Open Bio. 2016; 6: 285-302.
20.Yongye Huang, Yuan Lin, Li Tianye, Wang Anfeng, Li Zhanjun, Pang Daxin, Wang Bing, Ouyang Hongsheng. Valproic Acid Improves Porcine Parthenogenetic Embryo Development Through Transient Remodeling of Histone Modifiers. Cell Physiol Biochem. 2015; 37: 1463-73.
21.Yongye Huang, Ouyang Hongsheng, Xie Wanhua, Chen Xianju, Yao Chaogang, Han Yang, Han Xiaolei, Song Qi, Pang Daxin, Tang Xiaochun. Moderate expression of Wnt signaling genes is essential for porcine parthenogenetic embryo development. Cell Signal. 2013; 25: 778-85.
22.Yongye Huang, Ouyang Hongsheng, Yu Hao, Lai Liangxue, Pang Daxin, Li Zhanjun. Efficiency of porcine somatic cell nuclear transfer - a retrospective study of factors related to embryo recipient and embryos transferred. Biol Open. 2013; 2: 1223-8.
23.Yongye Huang, Tang Xiaochun, Xie Wanhua, Zhou Yan, Li Dong, Zhou Yang, Zhu Jianguo, Yuan Ting, Lai Liangxue, Pang Daxin, Ouyang Hongsheng. Vitamin C enhances in vitro and in vivo development of porcine somatic cell nuclear transfer embryos. Biochem Biophys Res Commun. 2011; 411: 397-401.
24.Yongye Huang, Tang Xiaochun, Xie Wanhua, Zhou Yan, Li Dong, Yao Chaogang, Zhou Yang, Zhu Jianguo, Lai Liangxue, Ouyang Hongsheng, Pang Daxin. Histone deacetylase inhibitor significantly improved the cloning efficiency of porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2011; 13: 513-20.
25. Zhou Yan, Yongye Huang, Xie Wanhua, Song Qi, Ji Yuan, Zhang Yanping, Ouyang Hongsheng, Lai Liangxue, Pang Daxin, Tang Xiaochun. Scriptaid affects histone acetylation and the expression of development-related genes at different stages of porcine somatic cell nuclear transfer embryo during early development. Chinese Sci Bull. 2013; 58: 2044-52.（共同一作）
26. Yongye Huang, Yuan Lin, Li Tianye, Liu Xiangfu, Yu Yang, Ouyang Hongsheng, Wang Bing. IWP2 impairs the development of porcine somatic cell nuclear transfer embryos via Wnt signaling pathway inactivation. Biomedical Reports. 2017; 7: 36-40.
27. Yongye Huang, Xie Wanhua, Yao Chaogang, Han Yang, Tan Guangyun, Zhou Yan, Zhu Jianguo, Pang Daxin, Li Zhanjun, Tang Xiaochun. Pluripotent-related gene expression analyses in single porcine recloned embryo. Biotechnol Lett. 2014; 36: 1161-9.
28. Ouyang Hongsheng, Han Jianyong, Yongye Huang. Pig Cloning Using Somatic Cell Nuclear Transfer. Methods Mol Biol. 2021; 2239: 1-18.
29.Du Xuguang, Feng Tao, Yu Dawei, Wu Yuanyuan, Zou Huiying, Ma Shuangyu, Feng Chong, Yongye Huang, Ouyang Hongsheng, Hu Xiaoxiang, Pan Dengke, Li Ning, Wu Sen. Barriers for Deriving Transgene-Free Pig iPS Cells with Episomal Vectors. Stem Cells. 2015; 33: 3228-38.
30.Han Xiaolei, Ouyang Hongsheng, Chen Xianju, Yongye Huang, Song Yuning, Zhang Mingjun, Pang Daxin, Lai Liangxue, Li Zhanjun. Aberrant expression of Igf2/H19 in porcine parthenogenetic fetuses and placentas. Anim Reprod Sci. 2013; 139: 101-8.
31.Wang Dongxu, Song Yuning, Yongye Huang, Duan Feifei, Lv Qingyan, Ouyang Hongsheng, Lai Liangxue, Li Zhanjun. Genomic imprinting analysis of Igf2/H19 in porcine cloned fetuses using parthenogenetic somatic cells as nuclear donors. Biotechnol Lett. 2014; 36: 1945-52.
32.Han Yang, Ouyang Hongsheng, Che Dongsheng, Chen Xianju, Yongye Huang, Elfaki elhag IA, Pang Daxin, Li Zhanjun. Elevated expression of vascular endothelial growth factor (VEGF) 120 in parthenogenetic porcine placentas. Biotechnol Lett. 2014; 36: 913-7.
33.Yuan Lin, Wang Anfeng, Yao Chaogang, Yongye Huang, Duan Feifei, Lv Qingyan, Wang Dongxu, Ouyang Hongsheng, Li Zhanjun, Lai Liangxue. Aberrant expression of Xist in aborted porcine fetuses derived from somatic cell nuclear transfer embryos. Int J Mol Sci. 2014; 15: 21631-43.
34.Luo Weiwei, Li Zhanjun, Li Peng, Yongye Huang, Han Yang, Yao Chaogang, Zhang Zhongzhan, Yan Honggang, Pang Daxin, Ouyang Hongsheng, Li Li. Expression of Cre recombinase in alveolar epithelial cells of the AQP2-Cre transgenic mini-pigs. Cell Physiol Biochem. 2014; 34: 1597-613.
35.Luo Weiwei, Li Zhanjun, Yongye Huang, Han Yang, Yao Chaogang, Duan Xinping, Ouyang Hongsheng, Li Li. Generation of AQP2-Cre transgenic mini-pigs specifically expressing Cre recombinase in kidney collecting duct cells. Transgenic Res. 2014; 23: 365-75.
36.Song Yuning, Lai Liangxue, Li Li, Yongye Huang, Wang Anfeng, Tang Xiaochun, Pang Daxin, Li Zhanjun, Ouyang Hongsheng. Germ cell-specific expression of Cre recombinase using the VASA promoter in the pig. FEBS Open Bio. 2016; 6: 50-5.
37.Dai Zhen, Wu Rong, Zhao Yicheng, Wang Kankan, Yongye Huang, Yang Xin, Xie Zicong, Tu Changchun, Ouyang Hongsheng, Wang Tiedong, Pang Daxin. Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathways. J Zhejiang Univ Sci B. 2014; 15: 466-73.
38.Yuan Lin, Yao Haobin, Xu Yuxin, Chen Mao, Deng Jichao, Song Yuning, Sui Tingting, Wang Yong, Yongye Huang, Li Zhanjun, Lai Liangxue. CRISPR/Cas9-Mediated Mutation of alphaA-Crystallin Gene Induces Congenital Cataracts in Rabbits. Invest Ophthalmol Vis Sci. 2017; 58: BIO34-BIO41.
39.Yuan Lin, Sui Tingting, Chen Mao, Deng Jichao, Yongye Huang, Zeng Jian, Lv Qingyan, Song Yuning, Li Zhanjun, Lai Liangxue. CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts. Sci Rep. 2016; 6: 22024.
40.Tan Guangyun, Ren Linzhu, Yongye Huang, Tang Xiaochun, Zhou Yang, Zhou Yan, Li Dong, Song Hongxiao, Ouyang Hongsheng, Pang Daxin. Isolation and culture of embryonic stem-like cells from pig nuclear transfer blastocysts of different days. Zygote. 2012; 20: 347-52.
41.Zhu Jianguo, Pang Daxin, Zhou Yang, Tang Xiaochun, Yongye Huang, Xie Wanhua, Gao Fei, Lai Liangxue, Zhang Mingjun, Ouyang Hongsheng. Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules. Cell Reprogram. 2012; 14: 99-105.
联系方式
地址：辽宁省沈阳市浑南区创新路195号，37000cm威尼斯生化与分子生物学研究所
E-mail：huangyongye88@163.com，huangyongye@mail.neu.edu.cn
邮编：110169