Name: Pu Zhao / 赵蒲
Title: M.D., Ph.D
Major:Neurobiology / Cell biology
Address: 3-11 Wen Hua Rd, Shenyang, Liaoning
Email: zhaopu6687700@mail.neu.edu.cn
教育经历
1999 – 2004 Lanzhou Medical College, Department of Preventive Medicine, School of Public Health
M.D. – Medicine
2004 – 2007 Fourth Military Medical University, Department of Cell Biology, School of Basic Medical Sciences
M.S. – Cell Biology
2007 – 2010 Fourth Military Medical University, Department of Cell Biology, School of Basic Medical Sciences
Ph.D. – Cell Biology
博士后及访学经历
2010.10 – 2012.09 Department of Medicine, Northwestern University Feinberg School of Medicine
Postdoctoral Fellow
2017.12 – 2019.01 Breast Caner Center, Baylor College of Medicine. Exchange Vistor
工作经历
2013 – 2019 Associate professor
Northeastern University College of Life and Health Sciences
研究方向
Cancer biology;
Neurodegenerative diseases;
Alternative pre-mRNA splicing.
科研项目
ACTIVE
National Natural Sciences Foundation of China 81971015 01/01/2020 – 12/31/2023
COMPLETED
The Fundamental Research Funds 01/01/2015 –12/31/2017
for Central Public Welfare Research Institutes of China N141008001/7
National Natural Sciences Foundation of China 31301108 01/01/2014 – 12/31/2016
National Undergraduate Innovative Test Program 151167 03/01/2015 – 05/31/2016
the Fundamental Research Funds 01/01/2014 – 12/31/2015
for Central Public Welfare Research Institutes of China N130520002
发表论文（#共同第一作者，*通讯作者）
[1] Li, D.D., Zhang, Y.H., Zhang, W.*, Zhao, P. *, Meta-Analysis of Randomized Controlled Trials on the Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease, Frontiers in neuroscience, 13 (2019) 472.
[2] Zhang, H., Brown, R.L., Wei, Y., Zhao, P., Liu, S., Liu, X., Deng, Y., Hu, X., Zhang, J., Gao, X.D., Kang, Y., Mercurio, A.M., Goel, H.L., Cheng, C.*, CD44 splice isoform switching determines breast cancer stem cell state, Genes & development, 33 (2019) 166-179.
[3] Wang, Z., Zhang, Y.H., Zhang, W., Gao, H.L., Zhong, M.L., Huang, T.T., Guo, R.F., Liu, N.N., Li, D.D., Li, Y., Wang, Z.Y.* and Zhao, P.* Copper chelators promote nonamyloidogenic processing of AbetaPP via MT1/2 /CREB-dependent signaling pathways in AbetaPP/PS1 transgenic mice. Journal of pineal research, 65 (2018) e12502.
[4] Wang, Z., Zhang, Y.H., Guo, C., Gao, H.L., Zhong, M.L., Huang, T.T., Liu, N.N., Guo, R.F., Lan, T., Zhang, W., Wang, Z.Y.* and Zhao, P.* Tetrathiomolybdate Treatment Leads to the Suppression of Inflammatory Responses through the TRAF6/NFkappaB Pathway in LPS-Stimulated BV-2 Microglia. Frontiers in aging neuroscience, 10 (2018) 9.
[5] Li, Y., Li, Z.X., Jin, T., Wang, Z.Y.* and Zhao, P.* Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases. Journal of Alzheimer's disease : JAD, 57 (2017) 395-409.
[6] Li, D.D., Zhang, W., Wang, Z.Y.* and Zhao, P.* Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies. Frontiers in aging neuroscience, 9 (2017) 300.
[7] Zhao, P., Xu, Y., Wei, Y., Qiu, Q., Chew, T.L., Kang, Y.and Cheng, C. The CD44s splice isoform is a central mediator for invadopodia activity. Journal of cell science, 129 (2016) 1355-1365.
[8] Wang, S.J., Cui, H.Y., Liu, Y.M., Zhao, P., Zhang, Y., Fu, Z.G., Chen, Z.N.andJiang, J.L. CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget, 6 (2015) 243-257.
[9] Hu, Y., Bi, X., Zhao, P., Zheng, H.andHuang, X. Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells. Molecules, 20 (2015) 20312-20319.
[10] Zhao, P., Damerow, M.S., Stern, P., Liu, A.H., Sweet-Cordero, A., Siziopikou, K., Neilson, J.R., Sharp, P.A.andCheng, C. CD44 promotes Kras-dependent lung adenocarcinoma. Oncogene, 32 (2013) 5186-5190.
[11] Zhang, W. #, Zhao, P. #, Xu, X.L., Cai, L., Song, Z.S., Cao, D.Y., Tao, K.S., Zhou, W.P., Chen, Z.N.and Dou, K.F. Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS One, 8 (2013) e67268.
[12] Cui, H.Y., Guo, T., Wang, S.J., Zhao, P., Dong, Z.S., Zhang, Y., Jiang, J.L., Chen, Z.N.andYu, X.L. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochemical and biophysical research communications, 419 (2012) 517-522.
[13] Zhao, P.#, Zhang, W. #, Wang, S.J #., Yu, X.L., Tang, J., Huang, W., Li, Y., Cui, H.Y., Guo, Y.S., Tavernier, J., Zhang, S.H., Jiang, J.L.andChen, Z.N. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology, 54 (2011) 2012-2024.
[14] Zhao, P. #, Zhang, W. #, Tang, J., Ma, X.K., Dai, J.Y., Li, Y., Jiang, J.L., Zhang, S.H.andChen, Z.N. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer science, 101 (2010) 387-395.
[15] Ma, X.K., Wang, L., Li, Y., Yang, X.M., Zhao, P., Tang, H., Zhu, P., Li, L.andChen, Z.N. HAb18G/CD147 cell-cell contacts confer resistance of a HEK293 subpopulation to anoikis in an E-cadherin-dependent manner. BMC cell biology, 11 (2010) 27.
[16] Wu, Y.M., Tang, J., Zhao, P., Chen, Z.N. and Jiang, J.L. Enhanced expression of Hab18g/CD147 and activation of integrin pathway in HCC cells under 3-D co-culture conditions. Cell biology international, 33 (2009) 199-206.
[17] Wu, Y.M., Tang, J., Zhao, P., Chen, Z.N. and Jiang, J.L. Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model. Experimental and molecular pathology, 87 (2009) 133-140.
[18] Tang, J., Wu, Y.M., Zhao, P., Jiang, J.L. and Chen, Z.N. Betaig-h3 interacts with alpha3beta1 integrin to promote adhesion and migration of human hepatoma cells. Experimental biology and medicine, 234 (2009) 35-39.
[19] Dai, J.Y., Dou, K.F., Wang, C.H., Zhao, P., Lau, W.B., Tao, L., Wu, Y.M., Tang, J., Jiang, J.L.andChen, Z.N. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC cancer, 9 (2009) 337.
[20] Tang, J., Wu, Y.M., Zhao, P., Yang, X.M., Jiang, J.L.andChen, Z.N. Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Cellular and molecular life sciences: CMLS, 65 (2008) 2933-2942.
[21] Ku, X.M., Liao, C.G., Li, Y., Yang, X.M., Yang, B., Yao, X.Y., Wang, L., Kong, L.M., Zhao, P. and Chen, Z.N. Epitope mapping of series of monoclonal antibodies against the hepatocellular carcinoma-associated antigen HAb18G/CD147. Scandinavian journal of immunology, 65 (2007) 435-443.